Antagonists of Wnt/β-catenin signalling in the periodontitis associated with type 2 diabetes and smoking

Autor: Tamires Szeremeske Miranda, Marcelo Henrique Napimoga, Magda Feres, Daniele Ferreira Cruz, Hélio Doyle Pereira da Silva, Letícia Macedo Marins, Poliana Mendes Duarte
Rok vydání: 2017
Předmět:
musculoskeletal diseases
0301 basic medicine
Adult
Genetic Markers
Male
medicine.medical_specialty
Type 2 diabetes
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Diabetes mellitus
Internal medicine
medicine
Humans
RNA
Messenger
Wnt Signaling Pathway
beta Catenin
Adaptor Proteins
Signal Transducing
Aged
Periodontitis
Analysis of Variance
biology
business.industry
Smoking
030206 dentistry
Middle Aged
medicine.disease
Chronic periodontitis
Up-Regulation
Wnt Proteins
030104 developmental biology
Endocrinology
DKK1
chemistry
Diabetes Mellitus
Type 2
RANKL
Case-Control Studies
Bone Morphogenetic Proteins
Chronic Periodontitis
biology.protein
Linear Models
Periodontics
Sclerostin
Population study
Intercellular Signaling Peptides and Proteins
Female
business
Biomarkers
Zdroj: Journal of clinical periodontology. 45(3)
ISSN: 1600-051X
Popis: Aim This study evaluated the levels of sclerostin (SOST) and Dickkopf (DKK)-1 in the chronic periodontitis (CP) associated with type 2 diabetes (DM) and/or smoking. Relationships between SOST, DDK1, RANKL, OPG, IL-1s, IL-6 and TNF-α, and pathogens were assessed. Material and Methods The study population included non-diabetic non-smokers (control), non-smokers with DM (DM group), non-diabetic smokers (S group) and smokers with DM (SDM group), all with CP. Serum and gingival levels of SOST, DKK1, RANKL, OPG, IL-1s, IL-6 and TNF-α were evaluated by multiplex immunoassay. Gene expressions of these biomarkers and subgingival levels of pathogens were assessed by qPCR. Results Gingival protein and/or mRNA levels of DKK1 and SOST were higher in subjects with DM and/or smoking than in controls (p
Databáze: OpenAIRE
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