Graded/Gradient Porous Biomaterials
| Autor: | Dan Sun, Xigeng Miao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pore size
Materials science porosity Review Functionally graded material bone lcsh:Technology Tissue engineering Biological property Highly porous General Materials Science pore size Porosity lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T technology industry and agriculture Biomaterial Stress shielding equipment and supplies gradient lcsh:TA1-2040 graded lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 Biomedical engineering biomaterials |
| Zdroj: | Materials, Vol 3, Iss 1, Pp 26-47 (2009) Materials |
| ISSN: | 1996-1944 |
| Popis: | Biomaterials include bioceramics, biometals, biopolymers and biocomposites and they play important roles in the replacement and regeneration of human tissues. However, dense bioceramics and dense biometals pose the problem of stress shielding due to their high Young’s moduli compared to those of bones. On the other hand, porous biomaterials exhibit the potential of bone ingrowth, which will depend on porous parameters such as pore size, pore interconnectivity, and porosity. Unfortunately, a highly porous biomaterial results in poor mechanical properties. To optimise the mechanical and the biological properties, porous biomaterials with graded/gradient porosity, pores size, and/or composition have been developed. Graded/gradient porous biomaterials have many advantages over graded/gradient dense biomaterials and uniform or homogenous porous biomaterials. The internal pore surfaces of graded/gradient porous biomaterials can be modified with organic, inorganic, or biological coatings and the internal pores themselves can also be filled with biocompatible and biodegradable materials or living cells. However, graded/gradient porous biomaterials are generally more difficult to fabricate than uniform or homogenous porous biomaterials. With the development of cost-effective processing techniques, graded/gradient porous biomaterials can find wide applications in bone defect filling, implant fixation, bone replacement, drug delivery, and tissue engineering. |
| Databáze: | OpenAIRE |
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