Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy
| Autor: | Mikhail A. Buldakov, Vladimir Riabov, M. V. Zavyalova, Julia Kzhyshkowska, Nadezhda V. Cherdyntseva, Irina Mitrofanova, Nadezhda Telegina |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_treatment Stabilin-1 Metastasis 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Tumor Microenvironment Immunology and Allergy Neoadjuvant therapy внутриопухолевая гетерогенность неоадъювантная химиотерапия CD68 Hematology Middle Aged Primary tumor Immunohistochemistry Neoadjuvant Therapy метастазы в лимфатических узлах макрофаги Lymphatic system Phenotype Treatment Outcome 030220 oncology & carcinogenesis Lymphatic Metastasis Female Adult medicine.medical_specialty Cell Adhesion Molecules Neuronal Immunology Receptors Lymphocyte Homing Antigens Differentiation Myelomonocytic Breast Neoplasms 03 medical and health sciences Breast cancer Antigens CD medicine Humans рак молочной железы Neoplasm Staging Tumor microenvironment business.industry Macrophages Cancer medicine.disease 030104 developmental biology Lymph Nodes Stromal Cells business Biomarkers |
| Zdroj: | Immunobiology. 2017. Vol. 222, № 1. P. 101-109 |
| Popis: | Breast cancer is the leading cause of cancer death in women worldwide with high morbidity and mortality. Tumor-associated macrophages (TAM) are major innate immune cells in the tumor microenvironment controlling primary tumor growth and metastasis. Neoadjuvant chemotherapy (NACT) is a conventional pre-operative treatment for breast cancer. In the present study we examined the distribution of TAM in five distinct intratumoral morphological compartments of human breast cancer and their correlation with clinical parameters after NACT. Our data indicated that CD68+ but not stabilin-1+ TAM in areas with parenchymal elements negatively correlate with lymphatic metastasis after NACT. However, in cases where lymphatic metastases were detected (28 out of 50 analyzed samples) both amount of CD68+ and stabilin-1+ macrophages in the areas with coarse fibrous stroma directly correlated with the number of positive lymph nodes. In patients with complete response to the preoperative NACT the average score of CD68 expression in the areas with coarse fibrous stroma was lower compared with cases of a partial response and stable disease. We concluded that function of TAM after NACT depends on their intratumoral localization and local tumor microenvironment which plays an important role in polarization of macrophages towards tumor-suppressive or tumor-supportive types. |
| Databáze: | OpenAIRE |
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