Allosensitization in Patients Receiving Multiple Blood Transfusions
| Autor: | G. C. Caldito, J. D. Cotelingam, Vishwas S. Sakhalkar, Linda M. Hawthorne, Diana M Veillon, K. Roberts, McCaskill D |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent Allosensitization Anemia education Anemia Sickle Cell General Biochemistry Genetics and Molecular Biology Immune system History and Philosophy of Science Antigen Isoantibodies Humans Medicine In patient Child Aged Autoantibodies Retrospective Studies business.industry Incidence General Neuroscience Autoantibody Infant Middle Aged medicine.disease Red blood cell medicine.anatomical_structure Blood Grouping and Crossmatching Blood Group Incompatibility Child Preschool Immunology Blood Group Antigens Female Immunization Erythrocyte Transfusion business |
| Zdroj: | Annals of the New York Academy of Sciences. 1054:495-499 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1196/annals.1345.072 |
| Popis: | Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and 153 dollars extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients. |
| Databáze: | OpenAIRE |
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