Bone turnover correlates with bone quantity but not bone microarchitecture in chronic hemodialysis
| Autor: | Dan Niculescu, Roxana Dusceac, Andra Caragheorgheopol, Catalina Poiana, Catalin Tacu, Cristiana David, Ramona Dobre, Madalina Sorohan |
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| Rok vydání: | 2020 |
| Předmět: |
Male
musculoskeletal diseases 0301 basic medicine medicine.medical_specialty Bone disease Endocrinology Diabetes and Metabolism medicine.medical_treatment Parathyroid hormone 030209 endocrinology & metabolism Bone and Bones End stage renal disease Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology Trabecular bone score Bone Density Renal Dialysis Internal medicine medicine Humans Orthopedics and Sports Medicine Aged Femoral neck biology business.industry General Medicine Middle Aged medicine.disease medicine.anatomical_structure Cancellous Bone Osteocalcin biology.protein Regression Analysis Female Bone Remodeling 030101 anatomy & morphology Hemodialysis business Biomarkers |
| Zdroj: | Journal of Bone and Mineral Metabolism. 38:597-604 |
| ISSN: | 1435-5604 0914-8779 |
| DOI: | 10.1007/s00774-020-01094-1 |
| Popis: | In chronic hemodialysis, high-turnover bone disease was associated with decreased bone mineral density (BMD), poor bone quality (chemical and structural), and increased fracture risk. Our aim was to correlate bone turnover markers (BTMs) with bone microarchitecture measured by trabecular bone score (TBS) before and after correction for BMD. We measured lumbar spine (LS), femoral neck, and 1/3 radius BMD and LS TBS by dual X-ray absorptiometry in 81 patients on permanent hemodialysis. Bone turnover was assessed using serum parathyroid hormone, osteocalcin, C-terminal crosslaps of type 1 collagen, procollagen 1 N-terminal propeptide (P1NP), and alkaline phosphatase (ALP). No patient had any partial or total parathyroidectomy and no previous or current treatment with anti-osteoporotic drugs. All BTMs correlated significantly with each other. Univariate regressions showed significant negative correlations between BTMs and BMD (best r = − 0.53, between P1NP and 1/3 radius Z-score) or BTMs and TBS (best r = − 0.27, p |
| Databáze: | OpenAIRE |
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