Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy

Autor: Yuqin Shen, Yu Mao, Wenwen Yan, Wenjun Xu, Lin Zhou, Zhi-Song Chen, Haoming Song, Yi Ni, Leming Wang
Rok vydání: 2017
Předmět:
0301 basic medicine
Cardiac function curve
Male
medicine.medical_specialty
Time Factors
Myocardial Ischemia
Pharmaceutical Science
chemical and pharmacologic phenomena
Inflammation
T-Lymphocytes
Regulatory
Ventricular Function
Left
Pathogenesis
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Left coronary artery
Internal medicine
medicine.artery
Genetics
Medicine
Aerobic exercise
Animals
030212 general & internal medicine
IL-2 receptor
Genetics (clinical)
Heart Failure
Ischemic cardiomyopathy
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-17
hemic and immune systems
Recovery of Function
medicine.disease
Exercise Therapy
Disease Models
Animal
030104 developmental biology
Echocardiography
Heart failure
Cardiology
Molecular Medicine
Th17 Cells
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Cardiomyopathies
Zdroj: Journal of cardiovascular translational research. 11(3)
ISSN: 1937-5395
Popis: Immune activation and inflammation participate in the progression of chronic heart failure (CHF). Th17 cells and CD4+CD25+ regulatory T (Treg) cells both come from naive Th cells and share reciprocal development pathways but exhibit opposite effects. We hypothesized that the Th17/Treg balance was impaired in patients with CHF, and exercise can improve it. Rats with ischemic cardiomyopathy were prepared by ligaturing the left anterior descending branch of the left coronary artery. Rats in training group were trained with treadmill; Th17 cells increased significantly while Treg cells significantly decreased in s by flow cytometry, and the peripheral blood level of IL-6, IL-17, and TNF-α was obviously elevated by ELISA assay. We found that Th17/Treg balance is impaired in CHF rats, suggesting Th17/Treg imbalance potentially plays a role in the pathogenesis of CHF. Exercise can improve Th17/Treg imbalance, which also improves cardiac function of CHF.
Databáze: OpenAIRE
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