Co-delivery of docetaxel and p53 gene from cationic nanoparticles based on poly (l-lactide) and low-molecular-weight polyethyleneimine (PEA)

Autor:	Qingfa, Guo, Fanyuan, Kong, Xiaoru, Pan, Shuhua, Cao
Rok vydání:	2022
Předmět:	Pharmaceutical Science General Medicine
Zdroj:	Pharmaceutical Development and Technology. 27:1049-1056
ISSN:	1097-9867 1083-7450
DOI:	10.1080/10837450.2022.2149793
Popis:	Recent findings revealed that low-concentration paclitaxel(DTX) could enhance cytotoxicity by upregulating p53 expression in lung cancer cell lines. So, co-delivery of DTX and RFP-p53 gene with PEA nanoparticles (NPs) was studied. The prepared DTX loaded PEA NPs (PEA/DTX) were characterized by particle size distribution, morphology, zeta potential, and crystallography and cytotoxicity. Results showed that the PEA/DTX NPs had a mall particle size (≤100 nm), moderate zeta potential (≥40 mV) and drug loading of 9.0%, DTX was released from PEA/DTX NPs in an extended period
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7684c05306bacccb689f77584ff7441f https://doi.org/10.1080/10837450.2022.2149793 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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