The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice
| Autor: | Antonio Gigliotti Rothfuchs, Reto Guler, Alan Sher, Lungile Matika, Muazzam Jacobs, Graeme I. Murray, Mohlopheni J. Marakalala, Frank Brombacher, Gordon D. Brown |
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| Rok vydání: | 2011 |
| Předmět: |
Ratón
Short Communication medicine.medical_treatment Immunology Syk Nerve Tissue Proteins Inflammation Biology Microbiology Mycobacterium tuberculosis Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Lectins C-Type Pulmonary pathology Receptor Tuberculosis Pulmonary Adaptor Proteins Signal Transducing 030304 developmental biology Mice Knockout 0303 health sciences Pattern recognition receptor Membrane Proteins Nuclear Proteins medicine.disease biology.organism_classification Immunity Innate 3. Good health CARD Signaling Adaptor Proteins Cytokine Infectious Diseases Cytokines Female Pulmonary disease medicine.symptom C-type lectin receptors CARD9 Dectin-1 Transcription Factors 030215 immunology |
| Zdroj: | Microbes and Infection / Institut Pasteur |
| ISSN: | 1286-4579 |
| DOI: | 10.1016/j.micinf.2010.10.013 |
| Popis: | There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice. |
| Databáze: | OpenAIRE |
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