Noninvasive Optical Imaging Method To Evaluate Postantibiotic Effects on Biofilm Infection In Vivo
| Autor: | Lin V. Sin, Jun Yu, Jagath L. Kadurugamuwa, Tony Purchio, Kevin P. Francis, Pamela R. Contag |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Diagnostic Imaging
Staphylococcus aureus medicine.drug_class Antibiotics Colony Count Microbial medicine.disease_cause Microbiology Mice Optical imaging In vivo medicine polycyclic compounds Bioluminescence Animals Pharmacology (medical) Experimental Therapeutics Antibiotics Antitubercular Pharmacology biology Biofilm DNA-Directed RNA Polymerases biochemical phenomena metabolism and nutrition Staphylococcal Infections biology.organism_classification rpoB Infectious Diseases Biofilms Luminescent Measurements Rifampin Bacteria |
| Popis: | Eradication of Staphylococcus aureus biofilms after rifampin treatment was tested in a mouse model of device-related infection by using biophotonic imaging. Following treatment, the bioluminescent signals decreased to undetectable levels, irrespective of the age of the biofilm. After the final treatment, the signals rebounded in a time-dependent manner and reached those for the untreated mice. Readministration of rifampin was unsuccessful in eradicating reestablished infections, with the rifampin MICs for such bacteria being increased and with the bacteria having point mutations in the rpoB gene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|