Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia: an analysis informing the development of recommendations for future core outcome set developers
| Autor: | Duffy, JMN, Hirsch, M, Ziebland, S, McManus, RJ, Duffy, James MN, Brown, Mark, Gale, Chris, Grobman, William, Fitzpatrick, Ray, Karumanchi, S Ananth, Lucas, Nuala, Magee, Laura, Mol, Ben, Stark, Michael, Thangaratinam, Shakila, Wilson, Mathew, Hooft, Janneke van't, von Dadelszen, Peter, Williamson, Paula R, Khan, Khalid S, Ziebland, Sue, McManus, Richard J, Outcom, Int Collaboration Harmonise |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Medical education
030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Sample (statistics) Outcome (game theory) Child health Decision Support Techniques 03 medical and health sciences Identification (information) Core (game theory) 0302 clinical medicine Pre-Eclampsia Pregnancy Prenatal Diagnosis Outcome Assessment Health Care Humans Medicine Female Thematic analysis business Set (psychology) Qualitative research |
| Zdroj: | BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY |
| Popis: | © 2019 Royal College of Obstetricians and Gynaecologists Objective: To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers. Design: Mixed methods study. Setting: A core outcome set for pre-eclampsia was used as an exemplar. Sample: A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews. Methods: Specific methods used to generate long lists of potential core outcomes were evaluated. Results: Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified. Conclusions: Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. Tweetable abstract: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers. |
| Databáze: | OpenAIRE |
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