Case-control study of risk factors of myelodysplastic syndromes according to World Health Organization classification in a Chinese population
| Autor: | Junmin Dai, Cuie Wu, Hejian Zou, Yongchen Yang, Minghua Gu, Hengjuan Sun, Guowei Lin, Hua Fu, Ling Lv, Xi Chen, Liming Bao, Xiang Gao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics China Pancytopenia Protective factor Antitubercular Agents Hair Dyes World Health Organization Young Adult Risk Factors Occupational Exposure Epidemiology Medicine Humans Risk factor Aged Aged 80 and over Anemia Refractory with Excess of Blasts business.industry Smoking Case-control study Hematology Odds ratio Middle Aged medicine.disease Confidence interval Relative risk Case-Control Studies Myelodysplastic Syndromes Educational Status Female business Refractory anemia with excess of blasts Drugs Chinese Herbal |
| Zdroj: | American journal of hematology. 86(2) |
| ISSN: | 1096-8652 |
| Popis: | Risk factors of mydelodysplastic syndromes (MDS) remain largely unknown. We conducted a hospital-based case-control study consisting of 403 newly diagnosed MDS patients according to World Health Organization classification and 806 individually gender and age-matched patient controls from 27 major hospitals in Shanghai, China, to examine relation of lifestyle, environmental, and occupational factors to risk of MDS. The study showed that all MDS (all subtypes combined) risk factors included anti tuberculosis drugs [odds ratio (OR)(adj) = 3.15; 95% confidence interval (CI) = 1.22-8.12] as an independent risk factor, benzene (OR(adj) = 3.73; 95% CI = 1.32-10.51), hair dye use (OR = 1.46; 95% CI = 1.03-2.07), new building and renovations (OR = 1.69; 95% CI = 1.11-2.00), pesticides (OR = 2.16; 95% CI = 1.22-3.82), and herbicides (OR = 5.33; 95% CI = 1.41-20.10) as relative risk factors. Risk factors of MDS subtype refractory cytopenia with multiple dysplasia (RCMD) were benzene (OR(adj) = 5.99; 95% CI = 1.19-30.16) and gasoline (OR(adj) = 11.44; 95% CI = 1.31-100.03) as independent risk factors, and traditional Chinese medicines (OR = 2.17; 95% CI = 1.15-4.07), pesticides (OR = 2.92; 95% CI = 1.37-6.25), and herbicides (OR = 12.00; 95% CI = 1.44-99.67) as relative risk factors. Smoking tobacco was significantly associated with refractory anemia with excess of blasts (RAEB) (OR(adj) = 2.43; 95% CI = 1.02-5.77). Education is shown as an independent protective factor against all MDS (OR(adj) = 0.90; 95% CI = 0.83-0.99) and RCMD (OR(adj) = 0.89; 95% CI = 0.79-0.99). These findings suggest that multiple modifiable behavioral, environmental, and occupational factors play a role in MDS etiology, and various MDS subtypes may have different susceptibility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text