Tetralogy of Fallot:A Population-Based Study of Epidemiology, Associated Malformations and Survival in Western Denmark 1984-1992
| Autor: | Ole Hansen, Gunner Nielsen, Ester Garne, Kristian Emmertsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Down syndrome Heart disease Heart malformation Denmark Population Congenital Abnormalities Epidemiology Prevalence medicine Humans Mortality Child education Tetralogy of Fallot Chromosome Aberrations education.field_of_study Chi-Square Distribution business.industry Infant Newborn Infant medicine.disease Survival Analysis VACTERL association Population based study Treatment Outcome Child Preschool Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Garne, E, Nielsen, G, Hansen, O K & Emmertsen, K 1999, ' Tetralogy of Fallot : A Population-Based Study of Epidemiology, Associated Malformations and Survival in Western Denmark 1984-1992 ', Scandinavian Cardiovascular Journal, vol. 33, pp. 45-48 . |
| Popis: | The study describes the epidemiology and mortality of tetralogy of Fallot (TOF) in a population-based study in Western Denmark. Ninety-two infants with TOF were born during 1984-1992. Prevalence was 3.01 per 10,000 livebirths. Karyotype anomalies were present in 12 (13%) and extracardiac malformations in 16 (17%) of the infants. Down syndrome, cleft palate, cleft lip and palate and combined skeletal, gastrointestinal and renal lesions (VACTERL association) were prevalent. Twenty-four infants died (26% of total), 13 (54%) of the deaths occurring during the first year of life. Mortality was significantly increased in infants with extracardiac malformations (50% vs 19%, p0.05). Eighteen deaths (75% of total deaths) occurred before corrective surgery and 7 of these deaths were sudden. Extracardiac malformation(s) in infants with TOF is a significant risk factor for death. The study stresses the importance of population-based studies for the assessment of mortality from congenital heart malformations. Overall mortality may be very different from mortality related to cardiac surgery. |
| Databáze: | OpenAIRE |
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