Maternal diet influences DNA damage, aortic telomere length, oxidative stress, and antioxidant defense capacity in rats
| Autor: | Susan E. Ozanne, Jane L. Tarry-Adkins, Malgorzata S. Martin-Gronert, Jian-Hua Chen, Roselle L. Cripps |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Antioxidant DNA damage medicine.medical_treatment Mothers medicine.disease_cause Biochemistry Antioxidants medicine.artery Internal medicine Lactation Genetics medicine Animals Molecular Biology Aorta biology Age Factors Telomere Molecular biology Diet Rats Oxidative Stress Low birth weight Endocrinology medicine.anatomical_structure Catalase Models Animal biology.protein Female medicine.symptom Oxidative stress DNA Damage Biotechnology |
| Zdroj: | The FASEB Journal. 22:2037-2044 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.07-099523 |
| Popis: | Low birth weight is associated with increased cardiovascular disease (CVD) in humans. Detrimental effects of low birth weight are amplified by rapid catch-up growth. Conversely, slow growth during lactation reduces CVD risk. Gestational protein restriction causes low birth weight, vascular dysfunction, and accelerated aging in rats. Atherosclerotic aortic tissue has shortened telomeres, and oxidative stress accelerates telomere shortening through generation of DNA single-strand breaks (ssbs). This study tested the hypothesis that maternal diet influences aortic telomere length through changes in DNA ssbs, antioxidant capacity, and oxidative stress. We used our models of gestational protein restriction followed by rapid catch-up growth (the recuperated group) and protein restriction during lactation (the postnatal low-protein [PLP] group). Southern blotting revealed fewer aortic DNA ssbs and subsequently fewer short telomeres (P |
| Databáze: | OpenAIRE |
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