Prognostic Values of Platelet-Associated Indicators in Resectable Lung Cancers
| Autor: | Min Tao, Yin-Ling Wang, Meng-Dan Xu, Wei Li, Jing-Jing Wang, Fei-Ran Gong, Wenjie Wang, Liu-Mei Shou, Kai Chen, Meng-Yao Wu, Xin-Xin Ge |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
Male Cancer Research medicine.medical_specialty Lung Neoplasms Platelet associated PLT Gastroenterology MPV 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Neoplasm Invasiveness Platelet Mean platelet volume Lung cancer Cancer death PDW Retrospective Studies 030304 developmental biology 0303 health sciences Lung business.industry Platelet Distribution Width Middle Aged Prognosis medicine.disease Small Cell Lung Carcinoma Survival Rate lung cancer medicine.anatomical_structure Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Female Original Article PCT business Mean Platelet Volume Follow-Up Studies |
| Zdroj: | Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 1533-0346 |
| DOI: | 10.1177/1533033819837261 |
| Popis: | Background: Lung cancer is the leading cause of cancer death. Platelet-related indictors, including platelet count, plateletcrit, mean platelet volume, and platelet distribution width, not only associate with morphology and functions of platelet but also correlate with tumor development and metastasis. In the present study, we investigated the values of platelet-related indictors in the prognosis evaluation of resectable lung cancers. Methods: In total, 101 patients with resectable lung cancer were recruited in this study. Patients were divided into 2 groups according to the median pretreatment values. To evaluate the individual value changes after treatment, we introduced the concept of post-/pretreatment ratio (≤1 indicated value was not increased after treatment, while >1 suggested increased value). Results: The high pretreatment platelet count level was correlated with larger tumor size. High pretreatment plateletcrit level was associated with more lymph nodes metastasis. Patients with high pretreatment plateletcrit level had worse overall survival, whereas pretreatment platelet count, mean platelet volume, and platelet distribution width levels were not correlated with outcomes. Surgery had no impact on the values of platelet count, plateletcrit, mean platelet volume, or platelet distribution width. Adjuvant chemotherapy significantly decreased the values of platelet count and plateletcrit, whereas it had no effect on the values of mean platelet volume or platelet distribution width. Whole course of treatment (surgery combined with adjuvant chemotherapy) significantly decreased the values of platelet count and platelet distribution width, whereas it had no effect on the values of plateletcrit or mean platelet volume. Post-/pretreatment platelet count, plateletcrit, mean platelet volume, and platelet distribution width ratios were not correlated with outcomes. Univariate analyses demonstrated that American Joint Committee on Cancer stage and pretreatment plateletcrit level were significant risk factors for prognosis. Cox regression analysis revealed that no factor independently associated with worse survival. Conclusion: Pretreatment plateletcrit level could be a potential prognostic factor in resectable lung cancers. |
| Databáze: | OpenAIRE |
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