Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging
| Autor: | R. Todd Constable, Xenophon Papademetris, Maulik P. Shah, Marcel P. Jackowski, Hilary P. Blumberg, Maolin Qiu, Brian Pittman, Jessica H. Kalmar, Lara G. Chepenik, Karen Tie, Gaolang Gong, Monique M. Jones, Fei Wang, Linda Spencer |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cingulate cortex Bipolar Disorder Models Neurological Statistics as Topic Central nervous system Gyrus Cinguli behavioral disciplines and activities Article White matter 03 medical and health sciences 0302 clinical medicine Fractional anisotropy medicine Humans 030212 general & internal medicine Bipolar disorder Anterior cingulate cortex Brain Mapping Emotional regulation medicine.disease 030227 psychiatry Psychiatry and Mental health Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Case-Control Studies Anisotropy Female Psychology Neuroscience Diffusion MRI |
| Zdroj: | British Journal of Psychiatry. 193:126-129 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.bp.107.048793 |
| Popis: | BackgroundConvergent evidence implicates white matter abnormalities in bipolar disorder. The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder.AimsTo test the hypothesis that bipolar disorder is associated with abnormal white matter integrity in the cingulum.MethodFractional anisotropy in the anterior and posterior cingulum was compared between 42 participants with bipolar disorder and 42 healthy participants using diffusion tensor imaging.ResultsFractional anisotropy was significantly decreased in the anterior cingulum in the bipolar disorder group compared with the healthy group (P=0.003); however, fractional anisotropy in the posterior cingulum did not differ significantly between groups.ConclusionsOur findings demonstrate abnormalities in the structural integrity of the anterior cingulum in bipolar disorder. They extend evidence that supports involvement of the neural system comprising the anterior cingulate cortex and its corticolimbic gray matter connection sites in bipolar disorder to implicate abnormalities in the white matter connections within the system provided by the cingulum. |
| Databáze: | OpenAIRE |
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