External Basic Hyperthermia Devices for Preclinical Studies in Small Animals
| Autor: | Gerard C. van Rhoon, Sergio Curto, Marjolein I Priester, Timo L.M. ten Hagen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Hyperthermia
Cancer Research Research groups Materials science Review 030218 nuclear medicine & medical imaging multimodal therapy 03 medical and health sciences Mild hyperthermia 0302 clinical medicine SDG 3 - Good Health and Well-being medicine Solid tumor RC254-282 standardization Reproducibility small animals preclinical hyperthermia Neoplasms. Tumors. Oncology. Including cancer and carcinogens Capacitive heating medicine.disease hyperthermia 3. Good health Oncology Preclinical testing 030220 oncology & carcinogenesis Treatment strategy Biomedical engineering |
| Zdroj: | Cancers Cancers, Vol 13, Iss 4628, p 4628 (2021) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13184628 |
| Popis: | Simple Summary The application of mild hyperthermia can be beneficial for solid tumor treatment by induction of sublethal effects on a tissue- and cellular level. When designing a hyperthermia experiment, several factors should be taken into consideration. In this review, multiple elementary hyperthermia devices are described in detail to aid standardization of treatment design. Abstract Preclinical studies have shown that application of mild hyperthermia (40–43 °C) is a promising adjuvant to solid tumor treatment. To improve preclinical testing, enhance reproducibility, and allow comparison of the obtained results, it is crucial to have standardization of the available methods. Reproducibility of methods in and between research groups on the same techniques is crucial to have a better prediction of the clinical outcome and to improve new treatment strategies (for instance with heat-sensitive nanoparticles). Here we provide a preclinically oriented review on the use and applicability of basic hyperthermia systems available for solid tumor thermal treatment in small animals. The complexity of these techniques ranges from a simple, low-cost water bath approach, irradiation with light or lasers, to advanced ultrasound and capacitive heating devices. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |