Factors Associated with Cognitive Outcomes After First-Ever Ischemic Stroke: The Impact of Small Vessel Disease Burden and Neurodegeneration
| Autor: | Kang Po Lee, Kuen Jer Tsai, Po Yu Lin, Sheng Hsiang Lin, Pi Shan Sung, Rwei Ling Yu, Chih Hung Chen, Hui Chen Su |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Hippocampus Gee 03 medical and health sciences Cognition Sex Factors 0302 clinical medicine Cost of Illness Surveys and Questionnaires Internal medicine Humans Medicine Prospective Studies 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Prospective cohort study Generalized estimating equation Stroke Ischemic Stroke business.industry General Neuroscience Montreal Cognitive Assessment General Medicine Odds ratio Middle Aged Mental Status and Dementia Tests medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Cerebral Small Vessel Diseases Cardiology Female Atrophy Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 83:569-579 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-210587 |
| Popis: | Background: Differences exist regarding post-stroke cognitive outcomes. Objective: The aim of this study investigates the potential factors associated with post-stroke cognitive performance and trajectories. Methods: We performed a prospective cohort study using serial monitoring of cognitive function over a 1-year period after a first-ever ischemic stroke. Small vessel disease (SVD) burden and hippocampal atrophy (HA) were evaluated using the modified cerebral small vessel disease scores (mCSVD) and medial temporal atrophy score (MTA) scores. A generalized estimating equation (GEE) model and a group-based trajectory model (GBTM) was used to analyze the potential factors associated with post-stroke cognitive outcomes. Results: A total of 112 patients were enrolled. The GEE model showed that all patients, regardless of initial cognitive performance, had a tendency to show an increase in the Montreal Cognitive Assessment over time. The cognitive performance was better in male patients with higher education levels (p = 0.046 and p |
| Databáze: | OpenAIRE |
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