Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020)
| Autor: | Zhou Sun, Jiaqi Xiao, Feng Gao, Peng Wang, Qiang Diao, Meixiang Gao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antineoplastic Agents
Pharmacology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship Epipodophyllotoxin Cell Line Tumor Drug Discovery medicine Structure–activity relationship Animals Humans Mode of action Etoposide 030304 developmental biology Podophyllotoxin 0303 health sciences Molecular Structure 010405 organic chemistry Organic Chemistry Stereoisomerism General Medicine 0104 chemical sciences Mechanism of action chemistry Drug Resistance Neoplasm medicine.symptom Pharmacophore Teniposide medicine.drug |
| Zdroj: | European journal of medicinal chemistry. 208 |
| ISSN: | 1768-3254 |
| Popis: | Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-sensitive and drug-resistant even multidrug-resistant cancer cells via inhibition of tubulin polymerization. Several podophyllotoxin/epipodophyllotoxin derivatives such as etoposide and teniposide have already been applied for cancer therapy, revealing their potential as putative anticancer drugs. Hybridization of podophyllotoxin/epipodophyllotoxin moiety with other anticancer pharmacophores is a promising strategy to develop novel drug candidates so as to overcome drug resistance and improve the specificity, and numerous of podophyllotoxin/epipodophyllotoxin hybrids exhibit excellent in vitro antiproliferative and in vivo anticancer potency. This review emphasizes the recent development of podophyllotoxin/epipodophyllotoxin hybrids with potential application for cancer therapy covering articles published between 2010 and 2020. The mechanisms of action, the critical aspects of design as well as structure-activity relationships were also summarized. |
| Databáze: | OpenAIRE |
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