Rifaximin Improves Systemic Hemodynamics and Renal Function in Patients With Alcohol-Related Cirrhosis and Ascites
| Autor: | Xanthi Xourgia, Athanasia Mouzaki, Andreas Fotopoulos, Konstantinos Pappas, Maria Rodi, Georgios N. Kalambokis, Epameinondas V. Tsianos |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Renal function Blood Pressure Pilot Projects Kidney Kidney Function Tests Plasma renin activity Gastroenterology Rifaximin Natriuresis chemistry.chemical_compound Liver Cirrhosis Alcoholic Internal medicine Renin medicine Humans Prospective Studies Cardiac Output Hepatology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Hemodynamics Ascites Middle Aged medicine.disease Rifamycins Anti-Bacterial Agents Endotoxins Treatment Outcome medicine.anatomical_structure Endocrinology chemistry Hyperdynamic circulation Vascular resistance business |
| Zdroj: | Clinical Gastroenterology and Hepatology. 10:815-818 |
| ISSN: | 1542-3565 |
| Popis: | BACKGROUND & AIMS: Circulating levels of endotoxin, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha increase with intestinal bacterial overgrowth and translocation, and are believed to be involved in the pathogenesis of hyperdynamic circulatory syndrome and functional renal failure in patients with advanced cirrhosis. METHODS: We investigated the effects of the antibiotic rifaximin on systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites. We measured mean arterial pressure, cardiac output (CO) by Doppler ultrasound, systemic vascular resistance (as the ratio of mean arterial pressure:CO), plasma rennin activity, levels of plasma aldosterone, the glomerular filtration rate by plasma clearance of technetium-99m-DTPA, natriuresis, levels of plasma endotoxin, and serum levels of IL-6 and TNF-alpha in 13 patients at baseline and after 4 weeks of treatment with rifaximin. RESULTS: Rifaximin treatment significantly reduced CO and significantly increased systemic vascular resistance, in association with a significant decrease in plasma rennin activity. The therapy also significantly increased the glomerular filtration rate and natriuresis while reducing levels of endotoxin, IL-6, and TNF-alpha. CONCLUSIONS: Intestinal decontamination with rifaximin improved systemic hemodynamics and renal function in patients with advanced cirrhosis. Clin Gastroenterol Hepatol |
| Databáze: | OpenAIRE |
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