Costs and cost-effectiveness of management of possible serious bacterial infections in young infants in outpatient settings when referral to a hospital was not possible: Results from randomized trials in Africa
| Autor: | Joshua Daba Hyellashelni, Yasir Bin Nisar, Shamim Qazi, Adejumoke I. Ayede, Fabian Esamai, Sachiyo Yoshida, Chineme Henry Anyabolu, Antoinette Tshefu, Peter Gisore, Jean-Serge Ngaima Kila, Adrien Lokangaka Longombe, Robinson D. Wammanda, Adegoke G Falade, Charu C. Garg, Lu Gram, Ebunoluwa A. Adejuyigbe, Rajiv Bahl |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
Financial Management Cost effectiveness Physiology Economics Cost-Benefit Analysis Health Care Providers Nurses Social Sciences law.invention Indirect costs Families 0302 clinical medicine Randomized controlled trial law Outpatients Medicine and Health Sciences Salaries 030212 general & internal medicine Medical Personnel Children Randomized Controlled Trials as Topic Multidisciplinary Pharmaceutics Respiration Bacterial Infections Health Care Costs Drug Prices Anti-Bacterial Agents Pharmacoeconomics Professions Breathing Medicine Gentamicin Infants medicine.drug Research Article medicine.medical_specialty Patients Science 030231 tropical medicine Penicillins 03 medical and health sciences Pharmacotherapy Health Economics Drug Therapy medicine Indirect Costs Humans Pharmacology business.industry Infant Newborn Infant Biology and Life Sciences Amoxicillin Clinical trial Health Care Regimen Age Groups Labor Economics Africa People and Places Population Groupings Gentamicins business Physiological Processes Finance |
| Zdroj: | PLoS ONE, Vol 16, Iss 3, p e0247977 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Introduction Serious bacterial neonatal infections are a major cause of global neonatal mortality. While hospitalized treatment is recommended, families cannot access inpatient treatment in low resource settings. Two parallel randomized control trials were conducted at five sites in three countries (Democratic Republic of Congo, Kenya, and Nigeria) to compare the effectiveness of treatment with experimental regimens requiring fewer injections with a reference regimen A (injection gentamicin plus injection procaine penicillin both once daily for 7 days) on the outpatient basis provided to young infants (0–59 days) with signs of possible serious bacterial infection (PSBI) when the referral was not feasible. Costs were estimated to quantify the financial implications of scaleup, and cost-effectiveness of these regimens. Methods Direct economic costs (including personnel, drugs and consumable costs) were estimated for identification, prenatal and postnatal visits, assessment, classification, treatment and follow-up. Data on time spent by providers on each activity was collected from 83% of providers. Indirect marginal financial costs were estimated for non-consumables/capital, training, transport, communication, administration and supervision by considering only a share of the total research and health system costs considered important for the program. Total economic costs (direct plus indirect) per young infant treated were estimated based on 39% of young infants enrolled in the trial during 2012 and the number of days each treated during one year. The incremental cost-effectiveness ratio was calculated using treatment failure after one week as the outcome indicator. Experimental regimens were compared to the reference regimen and pairwise comparisons were also made. Results The average costs of treating a young infant with clinical severe infection (a sub-category of PSBI) in 2012 was lowest with regimen D (injection gentamicin once daily for 2 days plus oral amoxicillin twice daily for 7 days) at US$ 20.9 (95% CI US$ 16.4–25.3) or US$ 32.5 (2018 prices). While all experimental regimens B (injection gentamicin once daily plus oral amoxicillin twice daily, both for 7 days), regimen C (once daily of injection gentamicin injection plus injection procaine penicillin for 2 days, thereafter oral amoxicillin twice daily for 5 days) and regimen D were found to be more cost-effective as compared with the reference regimen A; pairwise comparison showed regimen D was more cost-effective than B or C. For fast breathing, the average cost of treatment with regimen E (oral amoxicillin twice daily for 7 days) at US$ 18.3 (95% CI US$ 13.4–23.3) or US$ 29.0 (2018 prices) was more cost-effective than regimen A. Indirect costs were 32% of the total treatment costs. Conclusion Scaling up of outpatient treatment for PSBI when the referral is not feasible with fewer injections and oral antibiotics is cost-effective for young infants and can lead to increased access to treatment resulting in potential reductions in neonatal mortality. Clinical trial registration The trial was registered with Australian New Zealand Clinical Trials Registry under ID ACTRN 12610000286044. |
| Databáze: | OpenAIRE |
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