Permeability Alterations after Surgical Trauma in Normal Rabbit Peritoneum
| Autor: | Chrissi Hatzoglou, Molyvdas Pa, Maria Ioannou, G. Christodoulides, V. K. Kouritas, Konstantinos I. Gourgoulianis, Konstantinos Tepetes, M. Spyridakis |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Adhesion (medicine) Tissue Adhesions Icodextrin Permeability chemistry.chemical_compound Peritoneum Internal medicine medicine Animals Dimethindene Glucans Saline business.industry medicine.disease Amiloride Surgery Glucose medicine.anatomical_structure Endocrinology chemistry Permeability (electromagnetism) Dimetindene Female Rabbits Dimetindene maleate business medicine.drug |
| Zdroj: | European Surgical Research. 45:113-119 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000318146 |
| Popis: | Background: To investigate whether surgical trauma in a rabbit adhesion formation model and the administration of normal saline (N/S), icodextrin (ID) and/or dimetindene maleate (DM) changes the permeability of the normal rabbit parietal peritoneum. Materials and Methods: A total of 45 female rabbits were operated on for adhesion formation and were euthanized 10 days later. In some rabbits, ID or N/S was instilled intraabdominally during operation, whereas in others DM was infused intravenously. In others, ID plus DM or no agent was used. Specimens were obtained postoperatively and were mounted between Ussing chambers. Amiloride was used to investigate Na+ channels. Transmesothelial resistance (RTM) was determined as a permeability indicator. Results: Amiloride increased the RTM of both surfaces. Surgical trauma increased RTM and partially inhibited the effect of amiloride. ID and N/S increased RTM and inhibited the effect of amiloride. Use of DM did not change RTM and did not inhibit the effect of amiloride. Use of ID plus DM slightly increased RTM, but the effect of amiloride was blocked. Conclusions: Surgical trauma impairs the permeability of the normal rabbit parietal peritoneum. ID or N/S surmounted this effect, but DM did not, suggesting that surgical trauma is a diffuse process. Antiadhesion measures influence peritoneal physiology. |
| Databáze: | OpenAIRE |
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