| Autor: |
Georgios Solomou, Alina Finch, Asim Asghar, Chiara Bardella |
| Přispěvatelé: |
Solomou, Georgios [0000-0002-9795-0517], Bardella, Chiara [0000-0002-7780-2541], Apollo - University of Cambridge Repository |
| Rok vydání: |
2023 |
| Předmět: |
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| DOI: |
10.20944/preprints202304.0478.v1 |
| Popis: |
Altered metabolism is a common feature of many cancers and in some cases is a consequence of mutation in metabolic genes, such as the ones involved in Krebs cycle. Isocitrate dehydrogenase (IDH) gene is mutated in many gliomas and other cancers. Physiologically IDH converts isocitrate to αketoglutarate (αKG), but when mutated, IDH reduces αKG to D2-hydroxyglutarate (D2-HG). D2-HG accumulates at high levels in IDH mutant cancers, and in the last decade, a massive effort has been done to develop small inhibitors targeting mutant IDH. In this review, we summarize current knowledge about the cellular and molecular consequences of IDH mutations, and the therapeutic approached developed to target IDH mutant tumours, with a focus on gliomas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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