Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltration

Autor:	Satoshi Gando, Yuichiro Yanagida, Kunihiko Maekawa, Asumi Mizugaki, Atsushi Sawamura, Yuichi Ono, Masaki Kobayashi, Kenichi Katabami, Mineji Hayakawa, Ken Iseki, Takeshi Wada, Daisuke Miyamoto
Rok vydání:	2015
Předmět:	Critically ill business.industry Continuous hemodiafiltration Renal function Levofloxacin Dialysate flow Pharmacology Critical Care and Intensive Care Medicine Regimen Pharmacokinetics In vivo Clearance Medicine business Letter to the Editor medicine.drug
Zdroj:	Journal of Intensive Care
ISSN:	2052-0492
DOI:	10.1186/s40560-015-0089-0
Popis:	The aim of this study was to establish the pharmacokinetics of levofloxacin (LVFX) and determine the optimal dose of this drug in critically ill patients receiving continuous hemodiafiltration (CHDF). The results of in vivo and in vitro studies showed the pharmacokinetics of LVFX total clearance (CLtotal) according to the creatinine clearance (CLCre), dialysate flow (QD), and ultrafiltrate flow (QF), to be as follows: CLtotal (l/h) = 0.0836 × CLCre (ml/min) + 0.013 × body weight (kg) + 0.94(QD + QF) (l/h). The optimal dose of LVFX was expressed by the following formula: 50 × CLtotal. These results demonstrate that the usual dose of LVFX (500 mg) was sufficient for the patients evaluated in this study.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766bb2e747408a82610a523d1eacb96e https://doi.org/10.1186/s40560-015-0089-0 Zobrazit plný text záznamu Full text from SpringerLink