Endovascular Therapy for Erectile Dysfunction-Who Benefits Most? Insights From a Single-Center Experience
| Autor: | Stephen Wyler, Dagmar Schumacher, Hak Hong Keo, Dai Do Do, Christian Regli, Heinz Schoenhofen, Lorenz Räber, Stefanie Marggi, Nicolas Diehm, Tilmann Moeltgen, Martin C. Schumacher, Yasushi Ueki, Philipp Grimsehl |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Clinical Decision-Making Constriction Pathologic 030204 cardiovascular system & hematology Single Center Revascularization Endovascular therapy Impotence Vasculogenic 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Coated Materials Biocompatible Risk Factors medicine.artery Angioplasty medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Internal pudendal artery Prospective Studies Registries Aged business.industry Patient Selection Penile Erection Drug-Eluting Stents Recovery of Function Middle Aged medicine.disease Surgery Stenosis Erectile dysfunction Treatment Outcome Drug-eluting stent Feasibility Studies Cardiology and Cardiovascular Medicine business Angioplasty Balloon Switzerland Vascular Access Devices Penis |
| Zdroj: | Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 26(2) |
| ISSN: | 1545-1550 |
| Popis: | Purpose: To report the 1-year outcomes of a single-center, all-comers registry aimed to assess effectiveness and safety of endovascular revascularization for atherosclerotic erectile dysfunction (ED) in an unselected patient cohort. Materials and Methods: Between April 2016 and October 2017, 50 consecutive patients (mean age 59.6±10.3 years) underwent endovascular revascularization for ED owing to >50% stenosis in 82 erection-related arteries. Patients were treated by means of standard balloon angioplasty (16%), drug-coated balloon angioplasty (27%), or drug-eluting stent (55%) implantation. The primary feasibility outcome measure was the incidence of a minimum clinically relevant improvement of ≥4 in the 6-question International Index of Erectile Function Questionnaire (IIEF-6) score at 12 months. Clinical effectiveness was improvement in erectile function as quantified in the mean difference (MD) of the IIEF-15 score at 3 and 12 months as well as the mean changes in IIEF-15 questions 3 and 4. Results: Procedure success was achieved in 49 (98%) of 50 patients. At 12 months, 30 (65%) of 46 patients achieved a minimum clinically relevant improvement in the IIEF-6 score. The overall IIEF-15 score, as well as scores for questions 3 and 4, improved in 32 (65%) of 49 patients, 28 (57%) of 49 patients, and 29 (60%) of 48 patients, respectively. Change in the overall IIEF-15 score at 12 months was consistent among subgroups, except for elderly patients [MD −5.0 (95% CI −9.7 to −0.2), p=0.041] and those with hypertension [MD −11.0 (95% CI −20.5 to −1.5), p=0.025], who showed less improvement. Conclusion: Endovascular revascularization was safe and efficacious in the majority of ED patients through 1 year. |
| Databáze: | OpenAIRE |
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