A case study of mixed cryoglobulinaemia associated with peripheral neuropathy
| Autor: | D Wren, H Sharma, Joanna Sheldon, Rachel D. Wheeler, M Groves |
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| Rok vydání: | 2007 |
| Předmět: |
Weakness
Pathology medicine.medical_specialty Clinical Biochemistry Cryoglobulins Diagnosis Differential immune system diseases hemic and lymphatic diseases medicine Humans Rheumatoid factor Aged 80 and over biology Mononeuritis Multiplex business.industry Peripheral Nervous System Diseases General Medicine medicine.disease Purpura Peripheral neuropathy Cryoglobulinemia Immunoglobulin M biology.protein Female Differential diagnosis medicine.symptom business |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 44:566-569 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1258/000456307782268138 |
| Popis: | The clinical diagnosis of mixed cryoglobulinaemia is difficult due to heterogeneity in presentation. Symptoms include the classical triad of purpura, arthralgia and weakness, with one or more other organs involved. We discuss a case of cryoglobulinaemia that presented with sensory motor neuropathy and with features of mononeuritis multiplex syndrome, but which lacked other classical features. Laboratory testing revealed a profile typical of mixed cryoglobulins: immunoglobulin M (IgM) paraprotein, low fourth carbon (C4) and positive rheumatoid factor. Subsequent investigations failed to reveal an underlying infectious or neoplastic cause. This case demonstrates the need to include cryoglobulinaemia in the differential diagnosis for peripheral neuropathy, and the critical importance of using the correct collection procedure to isolate cryoglobulins. |
| Databáze: | OpenAIRE |
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