Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes

Autor:	M V Dolgushin
Rok vydání:	2019
Předmět:	0301 basic medicine Male Acid Phosphatase Primary Cell Culture Antitubercular Agents Administration Oral Gene Expression Dehydrogenase Glycerolphosphate Dehydrogenase Esterase General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Hydrolysis 0302 clinical medicine Lactate dehydrogenase Animals Outbred Strains Isoniazid Animals Lymphocytes chemistry.chemical_classification biology L-Lactate Dehydrogenase Succinate dehydrogenase Acid phosphatase Esterases General Medicine Phosphate Pyrazinamide Rats Succinate Dehydrogenase Drug Combinations 030104 developmental biology Enzyme chemistry Biochemistry Prothionamide biology.protein sense organs Rifampin 030217 neurology & neurosurgery Ethambutol Fluoroquinolones
Zdroj:	Bulletin of experimental biology and medicine. 168(4)
ISSN:	1573-8221
Popis:	Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766a515d5f68551c5e301c76fb29b200 https://pubmed.ncbi.nlm.nih.gov/32146623 Zobrazit plný text záznamu Full text from SpringerLink