Modulating effects of omega-3 fatty acids and pioglitazone combination on insulin resistance through toll-like receptor 4 in type 2 diabetes mellitus
| Autor: | Noha Abdel-Rahman, Salma M. Eraky, Laila A. Eissa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Peroxisome proliferator-activated receptor Down-Regulation Type 2 diabetes Biology Diet High-Fat Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences Insulin resistance Diabetes mellitus Malondialdehyde Internal medicine Fatty Acids Omega-3 medicine Animals chemistry.chemical_classification Toll-like receptor Pioglitazone business.industry Insulin Fatty acid Type 2 Diabetes Mellitus Cell Biology medicine.disease Combined Modality Therapy Rats Toll-Like Receptor 4 030104 developmental biology Cholesterol Endocrinology chemistry Diabetes Mellitus Type 2 Insulin Resistance business medicine.drug |
| Zdroj: | Endocrine Abstracts. |
| ISSN: | 1479-6848 |
| Popis: | Toll-like receptor 4 (TLR-4) plays important roles in innate immunity. Changes in the reduction-oxidation balance of tissues can lead to a pro-inflammatory state and insulin resistance. An action thought to be mediated by TLRs. Omega-3 fatty acids and Peroxisome Proliferator Activated Receptor gamma (PPAR-γ) agonists as pioglitazone are used for decreasing inflammation. The aim of this study is to investigate the anti-diabetic effects of combining omega -3 fatty acid with pioglitazone on type 2 diabetes, and the modifying effects on TLR-4. Type 2 diabetes was induced in male Sprague-Dawley rats by combination of high fat diet and low dose streptozotocin (35mg/kg). Diabetic rats were treated with omega-3 fatty acids (10% W/W diet), pioglitazone (20mg/kg), and their combination for 4 weeks. Omega-3 fatty acids and the combination treatment significantly decreased TLR-4 activation. Omega-3 fatty acids, pioglitazone, and their combination significantly decreased TLR-4 mRNA expression, hepatic malondialdehyde, total cholesterol and triglycerides levels, compared to diabetic group. Pioglitazone and the combination significantly decreased blood glucose levels and improved insulin resistance. In conclusion, combining omega-3 fatty acids with pioglitazone showed potential effects in lowering blood glucose levels and improving lipid profile and insulin resistance. Such effects are mediated through modulation of TLR-4. |
| Databáze: | OpenAIRE |
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