Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition

Autor: Petra H.M. Peeters, Verena Katzke, Kay-Tee Khaw, Inge Huybrechts, Susana Merino, Dagfinn Aune, Heiner Boeing, Tilman Kühn, Valeria Pala, Jordi de Batlle, Rosario Tumino, Miren Dorronsoro, Anne Tjønneland, Cecilie Kyrø, Eva Ardanaz, Nadia Slimani, Pietro Ferrari, Marie-Christine Boutron-Ruault, Maria Kritikou, Salvatore Panico, Giovanna Masala, Paolo Vineis, H. Bas Bueno-de-Mesquita, Jörn Schneede, Jin Young Park, Eric J. Duell, Maria Dolores Chirlaque, Francesca Mancini, Hanna Sternby, Björn Gylling, Vinciane Rebours, Ulrika Ericson, Guri Skeie, Antonia Trichopoulou, Elisabete Weiderpass, Kathryn E. Bradbury, Miguel Rodríguez-Barranco, Carlo La Vecchia
Přispěvatelé: Park, Jin Young, Bueno-de-Mesquita, H Ba, Ferrari, Pietro, Weiderpass, Elisabete, de Batlle, Jordi, Tjønneland, Anne, Kyro, Cecilie, Rebours, Vinciane, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, La Vecchia, Carlo, Kritikou, Maria, Masala, Giovanna, Pala, Valeria, Tumino, Rosario, Panico, Salvatore, Peeters, Petra H, Skeie, Guri, Merino, Susana, Duell, Eric J, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, Maria-Dolore, Ardanaz, Eva, Gylling, Björn, Schneede, Jörn, Ericson, Ulrika, Sternby, Hanna, Khaw, Kay-Tee, Bradbury, Kathryn E, Huybrechts, Inge, Aune, Dagfinn, Vineis, Paolo, Slimani, Nadia
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Cancer Research
pancreatic cancer
RATIONALE
Physiology
Folic Acid/administration & dosage
Clinical trials
0302 clinical medicine
Smoking/adverse effects
Medicine
Prospective Studies
Prospective cohort study
Non-U.S. Gov't
DNA METHYLATION
Pancreas cancer
PLASMA FOLATE
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin
sosialmedisin: 801
Research Support
Non-U.S. Gov't
Smoking
Hazard ratio
Middle Aged
European Prospective Investigation into Cancer and Nutrition
DEFICIENCY
Europe
Multicenter Study
Quartile
Oncology
030220 oncology & carcinogenesis
POPULATIONS
Female
Risk assessment
Life Sciences & Biomedicine
Adult
Nutritional Status
Research Support
Europe/epidemiology
03 medical and health sciences
Folic Acid
Journal Article
Humans
1112 Oncology and Carcinogenesis
Oncology & Carcinogenesis
Survival rate
Càncer de pàncrees
dietary folate intake
Proportional Hazards Models
EPIC PROJECT
Science & Technology
Proportional hazards model
business.industry
Pancreatic Neoplasms/epidemiology
Confidence interval
Pancreatic Neoplasms
EPIC study
Self Report
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine
Social medicine: 801
business
Assaigs clínics
Follow-Up Studies
Zdroj: International Journal of Cancer, 144(7), 1511. Wiley-Liss Inc.
Dipòsit Digital de la UB
Universidad de Barcelona
ISSN: 0020-7136
Popis: This is the peer reviewed version of the following article: Park, J.Y., Bueno-de-Mesquita, H.B., Ferrari, P., Weiderpass, E., de Batlle, J., Tjønneland, A. ... Slimani, N. (2018). Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition. International Journal of Cancer, 144(7), 1511-1521, which has been published in final form at https://doi.org/10.1002/ijc.31830. . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one‐carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy‐adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
Databáze: OpenAIRE
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