Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice
| Autor: | Bartoli Gm, Paola Palozza, Gabriella Calviello, Maria Emilia De Leo, Simona Serini |
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| Předmět: |
medicine.medical_specialty
Antioxidant canthaxanthin medicine.medical_treatment Iron Medicine (miscellaneous) Administration Oral Antioxidants BALB/c Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Mice antioxidant enzymes Settore MED/04 - PATOLOGIA GENERALE Internal medicine medicine Animals Canthaxanthin cantaxantin chemistry.chemical_classification Glutathione Peroxidase Mice Inbred BALB C Nutrition and Dietetics biology Superoxide Dismutase Glutathione peroxidase Glutathione Organ Size Malondialdehyde biology.organism_classification Endocrinology chemistry Biochemistry Liver biology.protein Female Lipid Peroxidation |
| Zdroj: | Scopus-Elsevier |
| Popis: | The 4,4'-diketo-beta-carotene, canthaxanthin, alters tocopherol status when fed to Balb/c mice, suggesting an involvement of carotenoids in the modulation of oxidative stress in vivo. We investigated further the modifications induced by an oral administration of canthaxanthin on lipid peroxidation, antioxidant enzymes and iron status in liver of Balb/c mice. Female 6-wk-old Balb/c mice were randomly divided into two groups (n = 10/group). The control group (C) received olive oil alone (vehicle) and the canthaxanthin-treated group (Cx) received canthaxanthin at a dose of 14 microg/(g body wt.d). The 15-d canthaxanthin treatment resulted in carotenoid incorporation but did not modify lipid peroxidation as measured by endogenous production of malondialdehyde (MDA). However, glutathione peroxidase activity was 35% lower (P |
| Databáze: | OpenAIRE |
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