Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology
Autor: | Jonathan McConathy, Jason M. Warram, Asim K. Bag, Anna G. Sorace, Neha Udayakumar, James M. Markert, Suzanne E. Lapi, Jianmei W. Leavenworth, Anna M. Wu, Benjamin B. Kasten |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Neuro oncology Nervous System Neoplasms Medicine (miscellaneous) Review Tumor response Theranostic Nanomedicine 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Tumor growth Medical physics Response criteria Pharmacology Toxicology and Pharmaceutics (miscellaneous) Pseudoprogression response business.industry imaging Immunotherapy Magnetic Resonance Imaging 3. Good health PET Positron-Emission Tomography 030220 oncology & carcinogenesis immunotherapy Treatment decision making Molecular imaging business neuro-oncology 030217 neurology & neurosurgery MRI |
Zdroj: | Theranostics |
ISSN: | 1838-7640 |
Popis: | Imaging plays a central role in evaluating responses to therapy in neuro-oncology patients. The advancing clinical use of immunotherapies has demonstrated that treatment-related inflammatory responses mimic tumor growth via conventional imaging, thus spurring the development of new imaging approaches to adequately distinguish between pseudoprogression and progressive disease. To this end, an increasing number of advanced imaging techniques are being evaluated in preclinical and clinical studies. These novel molecular imaging approaches will serve to complement conventional response assessments during immunotherapy. The goal of these techniques is to provide definitive metrics of tumor response at earlier time points to inform treatment decisions, which has the potential to improve patient outcomes. This review summarizes the available immunotherapy regimens, clinical response criteria, current state-of-the-art imaging approaches, and groundbreaking strategies for future implementation to evaluate the anti-tumor and immune responses to immunotherapy in neuro-oncology applications. |
Databáze: | OpenAIRE |
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