Hemodialysis Impact on Motor Function beyond Aging and Diabetes—Objectively Assessing Gait and Balance by Wearable Technology

Autor: Talal K. Talal, Bijan Najafi, Abdullah Hamad, Nishat Kulkarni, Fadwa Al-Ali, Rania Ibrahim, Hadi Rahemi, He Zhou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_treatment
Walking
lcsh:Chemical technology
Biochemistry
Analytical Chemistry
0302 clinical medicine
falls
lcsh:TP1-1185
Postural Balance
Instrumentation
hemodialysis
diabetes
Middle Aged
Atomic and Molecular Physics
and Optics
medicine.anatomical_structure
wearables
motor performance
Female
Hemodialysis
medicine.medical_specialty
STRIDE
030209 endocrinology & metabolism
frailty
gait
Article
End stage renal disease
Diabetes Complications
Wearable Electronic Devices
03 medical and health sciences
Physical medicine and rehabilitation
Renal Dialysis
Diabetes mellitus
medicine
Humans
Electrical and Electronic Engineering
end stage renal disease
Dialysis
Aged
Monitoring
Physiologic
Balance (ability)
business.industry
diabetic peripheral neuropathy
aging
balance
medicine.disease
Gait
Ankle
business
030217 neurology & neurosurgery
Zdroj: Sensors
Volume 18
Issue 11
Sensors, Vol 18, Iss 11, p 3939 (2018)
Sensors (Basel, Switzerland)
ISSN: 1424-8220
DOI: 10.3390/s18113939
Popis: Motor functions are deteriorated by aging. Some conditions may magnify this deterioration. This study examined whether hemodialysis (HD) process would negatively impact gait and balance beyond diabetes condition among mid-age adults (48&ndash
64 years) and older adults (65+ years). One hundred and ninety-six subjects (age = 66.2 ±
9.1 years, body-mass-index = 30.1 ±
6.4 kg/m2, female = 56%) in 5 groups were recruited: mid-age adults with diabetes undergoing HD (Mid-age HD+, n = 38) and without HD (Mid-age HD&minus
n = 40)
older adults with diabetes undergoing HD (Older HD+, n = 36) and without HD (Older HD&minus
n = 37)
and non-diabetic older adults (Older DM&minus
n = 45). Gait parameters (stride velocity, stride length, gait cycle time, and double support) and balance parameters (ankle, hip, and center of mass sways) were quantified using validated wearable platforms. Groups with diabetes had overall poorer gait and balance compared to the non-diabetic group (p <
0.050). Among people with diabetes, HD+ had significantly worsened gait and balance when comparing to HD&minus
(Cohen&rsquo
s effect size d = 0.63&ndash
2.32, p <
0.050). Between-group difference was more pronounced among older adults with the largest effect size observed for stride length (d = 2.32, p <
0.001). Results suggested that deterioration in normalized gait speed among HD+ was negatively correlated with age (r = &minus
0.404, p <
0.001), while this correlation was diminished among HD&minus
Interestingly, results also suggested that poor gait among Older HD&minus
is related to poor ankle stability, while no correlation was observed between poor ankle stability and poor gait among Older HD+. Using objective assessments, results confirmed that the presence of diabetes can deteriorate gait and balance, and this deterioration can be magnified by HD process. Among HD&minus
people with diabetes, poor ankle stability described poor gait. However, among people with diabetes undergoing HD, age was a dominate factor describing poor gait irrespective of static balance. Results also suggested feasibility of using wearable platforms to quantify motor performance during routine dialysis clinic visit. These objective assessments may assist in identifying early deterioration in motor function, which in turn may promote timely intervention.
Databáze: OpenAIRE
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