The cardiovascular effects of two new triazine antimalarials, BRL 50216 (Clociguanil) and BRL 6231
| Autor: | J.H. Shorter, R.H. Poyser, M.J. Nettleton |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Tachycardia
Reserpine Adrenergic receptor Blood Pressure Pharmacology Toxicology Antimalarials Electrocardiography Norepinephrine chemistry.chemical_compound Dogs Heart Rate Benzyl Compounds medicine Animals Drug Interactions Cardiac Output Nictitating Membrane Phentolamine Triazine CATS Dose-Response Relationship Drug Triazines Chemistry Respiration Hemodynamics Isoproterenol Vagus Nerve Femoral Vein Acetylcholine Femoral Artery Clociguanil Carotid Arteries Blood pressure Catecholamine Vascular Resistance medicine.symptom Sympathomimetic Effects Anti-Arrhythmia Agents Ethers Histamine medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 27:271-282 |
| ISSN: | 0041-008X |
| Popis: | Intravenous administration of 2 new triazine antimalarials, BRL 50216 (clociguanil) and BRL 6231, to anesthetized dogs and cats revealed that both these agents had sympathomimetic actions. However, these actions differed for the 2 compounds for whereas BRL 6231 evoked sympathomimetic responses (rise in blood pressure and tachycardia) by catecholamine release, BRL 50216 appeared to have a direct effect on adrenoceptors. BRL 50216 showed some specificity for β-adrenoceptors, but was much less active than isoproterenol in producing cardiac stimulation. In addition to its sympathomimetic effects, BRL 50216 had a quinidinelike antiarrhythmic action. Although many antimalarials are known to possess antiarrhythmic activity, few, if any, have previously been reported to produce sympathomimetic effects. |
| Databáze: | OpenAIRE |
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