Perinatal dioxin exposure in The Netherlands - a long-term follow-up
| Autor: | William M. C. Van Aalderen, Marike Leijs, Janna G. Koppe, Matthijs Westra, Thomas Vulsma, Johannes Oosting, Kees Olie, Gavin W. ten Tusscher |
|---|---|
| Přispěvatelé: | Earth Surface Science (IBED, FNWI) |
| Rok vydání: | 2008 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Pregnancy Breast development business.industry Birth weight Population Public Health Environmental and Occupational Health Physiology Environmental pollution medicine.disease Endocrinology Thyroid-stimulating hormone Internal medicine medicine education business Prospective cohort study General Environmental Science Cohort study |
| Zdroj: | International Journal of Environment and Health, 2(3/4), 429-438. Inderscience Enterprises Ltd. |
| ISSN: | 1743-4955 |
| DOI: | 10.1504/ijenvh.2008.020934 |
| Popis: | In 1987, a cohort study was initiated in the Amsterdam/Zaandam region of The Netherlands to study possible effects of dioxins on development and growth in a population of breastfed children selected after an optimal pregnancy and delivery and birth weight above 2500 grams. Effects on thyroid hormone metabolism, liver, haematology and immunology, and retinol binding protein were found in neonates. Follow-up was performed at the age of 2½ years, 8-12 years and 13-18 years. Neonatally an increase in free thyroxine and thyroid stimulating hormone was found, indicating a change in set point. An enhanced psychomotor maturation was seen at the age of 2½ years. Negative effects on lung function and on brain development (studied with neurophysiological tests of visuo-motoric and cognitive performance) were demonstrated in the age of 8-12 years. In adolescence preliminary results show a delay of almost 1 year in breast development in girls in association with higher (above 40 ng International Toxic Equivalents dioxin) prenatal dioxin exposure and again a negative effect on innate immunity. The abnormalities found indicate an increased vulnerability for more stressful circumstances. New chemicals comparable to dioxins or contaminated with dioxins should not be allowed on the market, or if already there, must be banned. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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