Caesalpinioflavone, a New Cytotoxic Biflavonoid Isolated from Caesalpinia pluviosa var. peltophoroides
| Autor: | Giovana C. Freitas, Marisa Ionta, João L. Baldim Zanin, Marcelo Henrique dos Santos, Evandro Luís de Oliveira Niero, João Henrique G. Lago, Marisi G. Soares, Murilo Massoni, Renata R. Schefer |
|---|---|
| Přispěvatelé: | Univ Fed Alfenas, Universidade de São Paulo (USP), Universidade Federal de São Paulo (UNIFESP) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
antiproliferative activity Cell cycle checkpoint Stereochemistry Electrospray ionization Chemical structure In vitro toxicology Biflavonoid General Chemistry biflavonoid Caesalpinia pluviosa var. peltophoroides chemistry Heteronuclear molecule cancer Viability assay Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of the Brazilian Chemical Society v.26 n.4 2015 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP Journal of the Brazilian Chemical Society, Volume: 26, Issue: 4, Pages: 804-809, Published: APR 2015 |
| Popis: | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FINEP The present study aimed to investigate the presence of compounds with antitumor activity in the plant Caesalpinia pluviosa var. peltophoroides. From bioactivity guided studies it was possible to isolate a new biflavonoid, named caesalpinioflavone, whose chemical structure was determined by spectroscopic (H-1 and C-13 nucler magnetic ressonace, homonuclear correlation spectroscopy and heteronuclear multiple-bond correlation spectroscopy) and spectrometric (high resolution electrospray ionization mass) methods. According to in vitro assays, caesalpinioflavone was effective in reducing the cell viability of tumor cell lines A549, MCF7, Hst578T and HTC. This effect was consequent of cell cycle arrest in G1/S transition (A549 and MCF7) and cytotoxic activity (Hs578T and HTC). Taken together, these data indicate that caesalpinioflavone has a promising antitumor activity. Univ Fed Alfenas, Inst Quim, BR-37130000 Alfenas, MG, Brazil Univ Fed Alfenas, Inst Ciencias Biomed, BR-37130000 Alfenas, MG, Brazil Univ São Paulo, Inst Quim, BR-05508000 São Paulo, SP, Brazil Univ São Paulo, Inst Ciencias Biomed, BR-05508000 São Paulo, SP, Brazil Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09920000 São Paulo, SP, Brazil Universidade Federal de São Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09920000 São Paulo, SP, Brazil Web of Science |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|