Study of acute hepatotoxicity of Equisetum arvense L. in rats
| Autor: | Jarbas de Brito, Bruno Battiston Vilela Vicente, Nilo César do Vale Baracho, Guilherme D'Andréa Saba Arruda, Brunno Cezar Framil Sanches |
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| Rok vydání: | 2009 |
| Předmět: |
Random allocation
Male Oral treatment Pathology medicine.medical_specialty Plant Extracts Acute Toxicity Equisetum Physiology Hepatic tissue Biology Acute toxicity Statistics Nonparametric Rats Random Allocation Liver Equisetum arvense L Toxicity Models Animal medicine Animals Surgery Rats Wistar Liver pathology Equisentum arvense |
| Zdroj: | Acta Cirúrgica Brasileira v.24 n.6 2009 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 1678-2674 |
| Popis: | PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water) and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively) for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats. |
| Databáze: | OpenAIRE |
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