Focal Adhesion Kinases in Adhesion Structures and Disease

Autor:	Pierre P. Eleniste, Angela Bruzzaniti
Rok vydání:	2012
Předmět:	biology Podosome Chemistry Integrin PTK2 Review Article Cell Biology Biochemistry Cell biology Focal adhesion Cellular and Molecular Neuroscience Invadopodia biology.protein Cell adhesion Paxillin Proto-oncogene tyrosine-protein kinase Src
Zdroj:	Journal of Signal Transduction
ISSN:	2090-1747 2090-1739
Popis:	Cell adhesion to the extracellular matrix (ECM) is essential for cell migration, proliferation, and embryonic development. Cells can contact the ECM through a wide range of matrix contact structures such as focal adhesions, podosomes, and invadopodia. Although they are different in structural design and basic function, they share common remodeling proteins such as integrins, talin, paxillin, and the tyrosine kinases FAK, Pyk2, and Src. In this paper, we compare and contrast the basic organization and role of focal adhesions, podosomes, and invadopodia in different cells. In addition, we discuss the role of the tyrosine kinases, FAK, Pyk2, and Src, which are critical for the function of the different adhesion structures. Finally, we discuss the essential role of these tyrosine kinases from the perspective of human diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765f842831989681baea17bb0f5c508b https://doi.org/10.1155/2012/296450 Zobrazit plný text záznamu Plný text ve formátu PDF