Design and Application of Antimicrobial Peptide Conjugates
| Autor: | Ines Neundorf, Andre Reinhardt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
photosensitizer medicine.drug_class Antimicrobial peptides Antibiotics Peptide Review antibiotics Catalysis lcsh:Chemistry Inorganic Chemistry antimicrobial peptides 03 medical and health sciences Organometallic Compounds medicine Animals Humans Photosensitizer Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy chemistry.chemical_classification Photosensitizing Agents organometallic complexes biology Chemistry Organic Chemistry General Medicine antimicrobial peptide conjugates Antimicrobial biology.organism_classification Combinatorial chemistry Computer Science Applications 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Biochemistry Nanoparticles Antibacterial activity Bacteria Antimicrobial Cationic Peptides Conjugate |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 17, Iss 5, p 701 (2016) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms17050701 |
| Popis: | Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong to the class of membrane-active peptides and usually act selectively against bacteria, fungi and protozoans. AMPs, but also peptide conjugates containing AMPs, have come more and more into the focus of research during the last few years. Within this article, recent work on AMP conjugates is reviewed. Different aspects will be highlighted as a combination of AMPs with antibiotics or organometallic compounds aiming to increase antibacterial activity or target selectivity, conjugation with photosensitizers for improving photodynamic therapy (PDT) or the attachment to particles, to name only a few. Owing to the enormous resonance of antimicrobial conjugates in the literature so far, this research topic seems to be very attractive to different scientific fields, like medicine, biology, biochemistry or chemistry. |
| Databáze: | OpenAIRE |
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