Ileal transcriptome analysis in obese rats induced by high-fat diets and an adenoviral infection
| Autor: | Lauren E. Shields, Yongming Sang, Alexis Pigg, Haijun Si, Frank Blecha, Eric R. Sang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Adenoviridae Infections Medicine (miscellaneous) 030209 endocrinology & metabolism Diet High-Fat Virus Transcriptome 03 medical and health sciences 0302 clinical medicine Ileum Internal medicine medicine Animals 030212 general & internal medicine Circadian rhythm Obesity Rats Wistar Gene Nutrition and Dietetics biology business.industry High fat diet Adenovirus serotype 36 biology.organism_classification medicine.disease Rats Endocrinology Adipogenesis business |
| Zdroj: | International journal of obesity (2005). 43(11) |
| ISSN: | 1476-5497 |
| Popis: | Obesity has become a worldwide epidemic affecting millions of people. Obesity and associated health consequences tend to be complicated by diverse causes and multi-systemic involvement. Previous studies have investigated obesity induced by a single factor, such as a high-fat diet (HF) of typical energy-dense food and infection by an adipogenic virus, such as a widely studied human adenovirus serotype 36 (Ad-36). In this study, we hypothesized and investigated the synergistic effect of two causal factors, HF and Ad-36, in obesity induction. The 7-week-old Wistar rats (n = 1214/group) were randomly divided into weight-matched groups and induced for obesity with mock-control, HF, Ad-36, or HF + Ad-36 for 8–30 weeks, and compared for obesity phenotype. A global transcriptomic RNA-Seq analysis was used to profile signature gene response pathways in ileal tissues from 8-week control and obese animals during this early phase of obesity induction. HF only and particularly co-administration of Ad-36 and HF (HF + Ad-36) induced significant obesity in rats (p |
| Databáze: | OpenAIRE |
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