Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity

Autor: Toshihiro Kasuga, Sungho Lee, Fukue Nagata, Takayoshi Nakano, Katsuya Kato
Rok vydání: 2020
Předmět:
Bone Regeneration
Composite number
02 engineering and technology
Bone tissue
Apatite
law.invention
Mice
law
Apatites
Materials Testing
Cells
Cultured
Bone mineral
therapeutic ions
Tissue Scaffolds
Metals and Alloys
bioactive glass
021001 nanoscience & nanotechnology
cell alignment
Electrospinning
bone quality
medicine.anatomical_structure
Bioactive glass
visual_art
visual_art.visual_art_medium
Original Article
0210 nano-technology
Materials science
Polyesters
0206 medical engineering
Biomedical Engineering
anisotropic scaffold
Biomaterials
Calcification
Physiologic
Cations
medicine
Animals
Bone regeneration
Nuclear Magnetic Resonance
Biomolecular
Osteoblasts
Silicates
Skull
Original Articles
medicine.disease
020601 biomedical engineering
Mice
Inbred C57BL
Animals
Newborn
Ceramics and Composites
Anisotropy
Glass
Calcification
Biomedical engineering
Zdroj: Journal of Biomedical Materials Research. Part a
ISSN: 1552-4965
Popis: Lee S., Nagata F., Kato K., et al. Development of orthophosphosilicate glass/poly(lactic acid) composite anisotropic scaffolds for simultaneous reconstruction of bone quality and quantity. Journal of Biomedical Materials Research - Part A, 109, 5, 788. https://doi.org/10.1002/jbm.a.37067.
Reconstruction of organ-specific architecture is necessary to recover the original organ function. The anisotropic structure of bone tissue is strongly related to the collagen fibril alignment and bone apatite crystal direction. Bone regeneration indicates following two main process; first, restoration of bone mineral density (BMD; bone quantity), and second, restoring bone apatite c-axis orientation (bone quality). In addition to BMD, bone quality is the most important factor among bone mechanical properties. Recovery of the original bone function requires development of novel scaffolds with simultaneous reconstruction of bone quality and quantity. Herein, novel orthophosphosilicate glass (PSG)/poly(lactic acid) composite anisotropic scaffolds were developed to control cell alignment and enhance bone formation, which are important for the simultaneous reconstruction of bone quality and quantity. The strategy to control cell alignment and bone formation involved designing anisotropic scaffolds in combination with the release of therapeutic ions by PSGs. The morphology of fibrous scaffolds containing PSGs was quantitatively designed using electrospinning. This successfully modulated cell alignment and subsequent bone apatite c-axis orientation along the fiber-oriented direction. The released silicate and Mg2+ ions from PSGs in scaffolds improved cell adhesion, proliferation, and calcification. To best of our knowledge, this is the first report demonstrating that the anisotropic scaffolds containing bioactive glasses regenerate bone tissues with simultaneous reconstruction of bone quality and quantity via stimulating osteoblasts by inorganic ions and designing morphology of scaffolds.
Databáze: OpenAIRE
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