Relationship between birth weight and adult lung function: controlling for maternal factors
| Autor: | J. G. Douglas, Carole A. Edwards, Liesl Osman, Doris M. Campbell, David J Godden |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Lung Diseases Male Pulmonary and Respiratory Medicine Vital capacity medicine.medical_specialty Pediatrics Epidemiology Birth weight Vital Capacity Population Gestational Age Cohort Studies FEV1/FVC ratio Pregnancy Forced Expiratory Volume medicine Birth Weight Humans education Retrospective Studies education.field_of_study business.industry Obstetrics Body Weight Smoking Infant Newborn Gestational age Middle Aged medicine.disease Body Height Parity Maternal Exposure Prenatal Exposure Delayed Effects Gestation Female Tobacco Smoke Pollution business Maternal Age Cohort study |
| Popis: | BACKGROUND: There is conflicting evidence on the "fetal origins hypothesis" of association between birth weight and adult lung function. This may be due to failure to control for confounding maternal factors influencing birth weight. In the present study access to birth details for adults aged 45-50 years who were documented as children to have asthma, wheezy bronchitis, or no respiratory symptoms provided an opportunity to investigate this association, controlling for maternal factors. METHODS: In 2001 the cohort was assessed for current lung function, smoking status, and respiratory symptoms. Birth details obtained from the Aberdeen Maternity and Neonatal Databank recorded birth weight, gestation, parity, and mother's age and height. RESULTS: 381 subjects aged 45-50 years were traced and tested for lung function; 323 (85%) had birth details available. A significant linear trend (p |
| Databáze: | OpenAIRE |
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