Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1-R-(pyridyl)ethyl ether terminus

Autor:	C. J. Woyden, Roger M. Freidinger, Mark G. Bock, Duane R. Reiss, Joseph M. Pawluczyk, Michelle S. Kuo, Amy G. Quigley, Douglas J. Pettibone, Maribeth T. Guidotti, E V Lis, D. S. Perlow, Peter D. Williams
Rok vydání:	1998
Předmět:	Stereochemistry Clinical Biochemistry Administration Oral Biological Availability Pharmaceutical Science Ether Oxytocin Biochemistry Chemical synthesis Oxytocin Antagonist Structure-Activity Relationship chemistry.chemical_compound Piperidines Oxazines Drug Discovery medicine Animals Humans Molecular Biology L-371 257 Chemistry Aryl Organic Chemistry Antagonist Benzoxazines Rats Alkoxy group Molecular Medicine Female medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:3081-3086
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(98)00568-x
Popis:	Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765c00dce9dedfe799c42f855a73f496 https://doi.org/10.1016/s0960-894x(98)00568-x Zobrazit plný text záznamu Full Text from ScienceDirect