Response criteria for NHL: Importance of ‘normal’ lymph node size and correlations with response rates
| Autor: | W. D. Carter, Bruce D. Cheson, D. L. Klippenstein, Sandra J. Horning, C. L. Varns, Bruce A. Peterson, Antonio J. Grillo-Lopez, C. D. Shen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Antineoplastic Agents Antibodies Monoclonal Murine-Derived Overall response rate Reference Values medicine Humans Response criteria Lymph node Complete response Retrospective Studies business.industry Time to progression Lymphoma Non-Hodgkin Antibodies Monoclonal Hematology medicine.disease Lymphoma Surgery Non-Hodgkin's lymphoma Treatment Outcome medicine.anatomical_structure Oncology Disease Progression Rituximab Lymph Nodes Nuclear medicine business medicine.drug |
| Zdroj: | Annals of Oncology. 11:399-408 |
| ISSN: | 0923-7534 |
| DOI: | 10.1023/a:1008332713631 |
| Popis: | Summary Background Oncologic literature cites many different definitions of critical response measurements. Patients and methods Response criteria (RC) for non-Hodgkin’s lymphoma (NHL) were developed by lymphoma experts, endorsed by international lymphoma clinicians, and applied to a 166-patient rituximab (Rituxan®, MabThera®) trial by a third-party, blinded panel of NHL experts (LEX-COR). Retrospectively, we analyzed this data using variations of the original RC and comparing with recently published RC. Results The definition of a ‘normal’ lymph node affected the complete response (CR) rate (≤ 1.0 × 1.0 cm, 6%; ≤ 1.5 × 1.5 cm, 18%; ≤ 2.0 × 2.0 cm, 28%); overall response rate (ORR) was not affected. CR rates increased progressively without ≥ 28 days response confirmation: 12% vs. 6% (≤ 1.0 × 1.0 cm), 26% vs. 18% (≤ 1.5 × 1.5 cm), and 36% vs. 28% (≤ 2.0 × 2.0 cm). CR rate and duration of response (DR) were unaffected when only the six largest, rather than all lesions, were measured. When the new RC were applied, CR rate (32%) was higher and DR (13.9 months) and time to progression (15.6 months) were shorter in complete responders. Conclusions Standard RC must be consistently and rigorously applied for accurate comparisons between studies. |
| Databáze: | OpenAIRE |
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