Therapeutic repetitive Transcranial Magnetic stimulation (rTMS) for neurological dysfunction in Degenerative cervical Myelopathy: An unexplored opportunity? Findings from a systematic review
| Autor: | Fahim Anwar, Benjamin Davies, Mark R. N. Kotter, Maaz A. Khan, Aref-Ali Gharooni, Xiaoyu Yang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment MEDLINE Spinal Cord Diseases 03 medical and health sciences Myelopathy 0302 clinical medicine Physical medicine and rehabilitation Quality of life Physiology (medical) Neuroplasticity medicine Humans cardiovascular diseases Spinal cord injury Rehabilitation Neuronal Plasticity business.industry General Medicine musculoskeletal system medicine.disease Transcranial Magnetic Stimulation Neuromodulation (medicine) Transcranial magnetic stimulation Treatment Outcome Neurology 030220 oncology & carcinogenesis cardiovascular system Quality of Life Surgery Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 90 |
| ISSN: | 1532-2653 |
| Popis: | Degenerative Cervical Myelopathy (DCM) is one of the commonest causes of non-traumatic Spinal Cord Injury (SCI) leading to significant neurological impairments and reduced health-related quality of life. Guidelines recommend surgical intervention to halt disease progression in moderate-to-severe cases, and whilst many do experience neurological recovery, this is incomplete leading to lifelong disability. A James Lind Alliance (JLA) research priority setting partnership for DCM highlighted novel therapies and rehabilitation as top 10 research priority in DCM. Neurological recovery following decompressive surgery in DCM has been attributed neuroplasticity, and therapies influencing neuroplasticity are of interest. Electrical neuromodulation interventions such as repetitive Transcranial Magnetic Stimulation (rTMS), are being increasingly explored in related fields such as spinal cord injury to improve recovery and symptoms. The aim of this systematic review was to determine the role and efficacy of rTMS as a therapeutic tool in managing neurological dysfunction in DCM. We searched the databases of Medline, EMBASE, CINAHIL and Cochrane Central Register of Controlled Trials (CENTRAL). No studies were identified that had investigated the therapeutic use of rTMS in DCM. A significant number of studies had explored TMS based neurophysiological assessments indicating its role as a screening and prognostication tool in DCM. Post-operative rehabilitation interventions including TMS and non-operative management of DCM is a field which requires further investigation, as required in the AO Spine JLA DCM research priorities. rTMS is a safe neuromodulatory intervention and may have a role in enhancing recovery in DCM. Further research in these fields are required. |
| Databáze: | OpenAIRE |
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