Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease
| Autor: | Marco Catani, Erminia Mariani, Paola Mattioli, Umberto Senin, Roberta Cecchetti, Patrizia Mecocci, Patrizia Rinaldi, Maria Cristina Polidori, Antonio Metastasio, Antonio Cherubini |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Vitamin
Male Aging medicine.medical_specialty Antioxidant Erythrocytes GPX3 medicine.medical_treatment Matched-Pair Analysis Ascorbic Acid medicine.disease_cause Antioxidants chemistry.chemical_compound Plasma Apolipoproteins E Alzheimer Disease Reference Values Internal medicine mental disorders Medicine Dementia Humans Vitamin E Vitamin A Aged Aged 80 and over Glutathione Peroxidase Vitamin C business.industry Superoxide Dismutase General Neuroscience medicine.disease Carotenoids Uric Acid Oxidative Stress Endocrinology chemistry Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease business Cognition Disorders Oxidative stress Developmental Biology |
| Zdroj: | Neurobiology of aging. 24(7) |
| ISSN: | 0197-4580 |
| Popis: | In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer’s disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids including lutein, zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotene) antioxidant micronutrients as well as activities of plasma and red blood cell (RBC) superoxide dismutase (SOD) and of plasma glutathione peroxidase (GPx) were measured in 25 patients with MCI, 63 AD patients and 53 controls. Peripheral levels and activities of antioxidants were similarly lower in MCI and AD patients as compared to controls. As MCI may represent a prodromal stage of AD, and oxidative damage appears to occur as one of the earliest pathophysiological events in AD, an increased intake of antioxidants in patients with MCI could be helpful in lowering the risk of conversion to dementia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect