Roles of leader and follower cells in collective cell migration
| Autor: | Lei Qin, Dazhi Yang, Huiling Cao, Weihong Yi, Guozhi Xiao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cognitive science
0303 health sciences Movement (music) Collective cell migration Cancer metastasis Cell Biology Animal development Cell movement Tissue repair Biology Models Biological Collective migration 03 medical and health sciences 0302 clinical medicine Spatio-Temporal Analysis Cell Movement Phenomenon Animals Humans Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology Perspectives |
| Zdroj: | Molecular Biology of the Cell |
| ISSN: | 1939-4586 1059-1524 |
| Popis: | Collective cell migration is a widely observed phenomenon during animal development, tissue repair, and cancer metastasis. Considering its broad involvement in biological processes, it is essential to understand the basics behind the collective movement. Based on the topology of migrating populations, tissue-scale kinetics, called the “leader–follower” model, has been proposed for persistent directional collective movement. Extensive in vivo and in vitro studies reveal the characteristics of leader cells, as well as the special mechanisms leader cells employ for maintaining their positions in collective migration. However, follower cells have attracted increasing attention recently due to their important contributions to collective movement. In this Perspective, the current understanding of the molecular mechanisms behind the “leader–follower” model is reviewed with a special focus on the force transmission and diverse roles of leaders and followers during collective cell movement. |
| Databáze: | OpenAIRE |
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