Isolation and envelope sequence of a highly divergent HIV-1 isolate: definition of a new HIV-1 group
| Autor: | Denise Guetard, Caroline Quillent, Luc Montagnier, Pierre Charneau, S. Chamaret, François Clavel, Gérard Rémy, Jacques H. M. Cohen, Andrew M. Borman |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Isolation (health care) Molecular Sequence Data Human immunodeficiency virus (HIV) Biology medicine.disease_cause Genes env Virus Acquired immunodeficiency syndrome (AIDS) Viral Envelope Proteins Group (periodic table) Virology medicine Humans Amino Acid Sequence Phylogeny Sequence (medicine) DNA Primers Acquired Immunodeficiency Syndrome Phylogenetic tree Base Sequence Sequence Homology Amino Acid virus diseases Genetic Variation medicine.disease Outgroup HIV-1 Female |
| Zdroj: | Virology. 205(1) |
| ISSN: | 0042-6822 |
| Popis: | We report here the isolation and envelope sequence of a divergent HIV-1 isolate from a French woman with AIDS. This virus, HIV-1 VAV , is closely related to the recently described Cameroonian viral isolates HIV-1 ANT70 and HIV-1 MVP5180 , until now designated HIV-1 subtype O. Phylogenetic analysis reveals that the three viruses are equidistant from one another and that their mutual divergence is similar to what has been reported between the more conventional HIV-1 subtypes. Therefore, these three viruses could be included in a new viral group, HIV-1 group O (outgroup), distinct from the cluster of other HIV-1 isolates, which we will refer to as group M (Major group). The HIV-1 group O is currently emerging in western central Africa but its spread in Europe has already started. |
| Databáze: | OpenAIRE |
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