An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?
| Autor: | Heinrich Meier, Markus Follmann, Alexander Hillisch, Monika H. Schmitt, Helmut Haning, Andreas Steinmeyer, Hans Briem |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Quality Control Process management Drug Industry Drug discovery Computer science media_common.quotation_subject Novelty Chemical space Odds High-Throughput Screening Assays Small Molecule Libraries 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Lead (geology) 030220 oncology & carcinogenesis Drug Discovery Quality (business) media_common |
| Zdroj: | Drug discovery today. 24(3) |
| ISSN: | 1878-5832 |
| Popis: | Pharmaceutical companies often refer to ‘screening their library’ when performing high-throughput screening (HTS) on a corporate compound collection to identify lead structures for small-molecule drug discovery programs. Characteristics of such a library, including the size, chemical space covered, and physicochemical properties, often determine the success of a screening campaign. Therefore, strategies to maintain and enhance the overall quality of screening collections are crucial to stay competitive and to cope with the ‘novelty erosion’ that is observed gradually. The Next Generation Library Initiative (NGLI), the enhancement of Bayer’s HTS collection by 500 000 newly designed compounds within 5 years, is addressing exactly this challenge. Here, we describe this collaborative project, which involves all internal medicinal chemists in a crowd-sourcing approach, as well as selected external partners, to reach this ambitious goal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect