Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia
| Autor: | Anna Bochyńska, Magdalena Gugała-Iwaniuk, Anna Wiśniewska, Ksenia Slawinska, Hanna Wehr, Agnieszka Ługowska, Danuta Ryglewicz, Ałła Graban, Wanda Łojkowska, Małgorzata Bednarska-Makaruk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Leptin Male Aging medicine.medical_specialty Inflammatory markers Adipokine 03 medical and health sciences 0302 clinical medicine Insulin resistance Adipokines Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction Resistin Vascular dementia Abdominal obesity Aged Aged 80 and over Adiponectin business.industry Dementia Vascular nutritional and metabolic diseases medicine.disease Up-Regulation 030104 developmental biology Endocrinology Case-Control Studies Obesity Abdominal Female Geriatrics and Gerontology medicine.symptom Inflammation Mediators Insulin Resistance business Gerontology 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Biomarkers Research Article |
| Zdroj: | Biogerontology |
| ISSN: | 1573-6768 |
| Popis: | The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer's disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia. |
| Databáze: | OpenAIRE |
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