Taenia solium dUTPase: A potential target for anti-human cysticercosis
| Autor: | Xue-nong Luo, Wanzhong Jia, Zhenyong Liu, Xuepeng Cai, Zhizhong Jing, Yadong Zheng |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Putative protein
Cysticercosis Veterinary (miscellaneous) Gene Amplification Biology medicine.disease Virology medicine.drug_formulation_ingredient Infectious Diseases Insect Science DUTP pyrophosphatase parasitic diseases Taenia solium Pyrimidine metabolism medicine Animals Humans Parasitology Amino Acid Sequence Pyrophosphatases Gene Peptide sequence Phylogeny |
| Zdroj: | Acta tropica. 101(3) |
| ISSN: | 0001-706X |
| Popis: | dUTPase plays an essential role in pyrimidine metabolism in many organisms. In this study we report the dUTPase-encoding gene (Tdut) from Taenia solium oncospheres and larvae. Alignment reveals that the putative protein contains five conserved motifs that are often found in many characterized dUTPases. The deduced amino acid sequence has only 65.2% identity with human dUTPases. This low identity encourages its use for the design of new drugs against cysticercosis. |
| Databáze: | OpenAIRE |
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