The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer
| Autor: | Bernhard Meier, Ton de Vries, Joanna J. Wykrzykowska, Pedro Eerdmans, Peter Jüni, Carlo Di Mario, Stanislaw Trznadel, Karsten Lenk, Robert-Jan van Geuns, Paweł Buszman, Stephan Windecker, Paweł Tyczyński, Gerrit-Anne van Es, Volker Klauss, Franz R. Eberli, Thomas Ischinger, Roberto Corti, Scot Garg, Marie-Claude Morice, Axel Linke, Patrick W. Serruys, William Wijns |
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| Přispěvatelé: | Cardiology, Radiology & Nuclear Medicine, University of Zurich |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Polymers medicine.medical_treatment Myocardial Infarction 610 Medicine & health Coronary Artery Disease Kaplan-Meier Estimate 2705 Cardiology and Cardiovascular Medicine Internal medicine Durable polymer Absorbable Implants Clinical endpoint Medicine Humans Myocardial infarction cardiovascular diseases Acute Coronary Syndrome Angioplasty Balloon Coronary Aged Sirolimus Protein synthesis inhibitor business.industry Stent Drug-Eluting Stents Middle Aged medicine.disease equipment and supplies Surgery surgical procedures operative Treatment Outcome Drug-eluting stent Cardiology 10209 Clinic for Cardiology Female Cardiology and Cardiovascular Medicine business Mace medicine.drug Follow-Up Studies |
| Zdroj: | EuroIntervention, 6(8), 928-935. EuroPCR Garg, Scot; Wykrzykowska, Joanna; Serruys, Patrick W; de Vries, Ton; Buszman, Pawel; Trznadel, Stanislaw; Linke, Axel; Lenk, Karsten; Ischinger, Thomas; Klauss, Volker; Eberli, Franz; Corti, Roberto; Wijns, William; Morice, Marie-Claude; di Mario, Carlo; Tyczynski, Pawel; van Geuns, Robert Jan; Eerdmans, Pedro; van Es, Gerrit-Anne; Meier, Bernhard; ... (2011). The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer. EuroIntervention, 6(8), pp. 928-935. Toulouse: Europa Digital & Publishing |
| ISSN: | 1774-024X |
| Popis: | Aims: This study investigated the differences in clinical outcomes between patients with bifurcation lesions (BL) treated with a biolimus-eluting stent (BES) with a biodegradable polymer, and a sirolimus-eluting stent (SES) with a durable polymer. Methods and results: The clinical outcomes were assessed in the 497 patients (BES 258, SES 239) enrolled in the multicentre, randomised LEADERS trial who underwent treatment of Y1 BL (total=534 BL). At 12-months follow-up there was no significant difference in the primary endpoint of MACE, a composite of cardiac death, myocardial infarction and clinically indicated target vessel revascularisation (BES 12.8% vs. SES 16.3%, p=0.31). Patients treated with BES had comparable rates of cardiac death (BES 2.7% vs. SES 2.9%, p=1.00), numerically higher rates of myocardial infarction (BES 8.9% vs. SES 5.4%, p=0.17), and significantly lower rates of clinically indicated target vessel revascularisation (4.3% vs. 11.3%, p=0.004) when compared to those treated with SES. The rate of stent thrombosis at 12-months was 4.3% and 3.8% for BES and SES, respectively (p=0.82). Conclusions: In the treatment of BL the use of BES lead to superior efficacy and comparable safety compared to SES. © Europa Edition 2011. All rights reserved. |
| Databáze: | OpenAIRE |
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